Hepatic injury

Hepatic ischemia-reperfusion injury.

24 Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor that induces inflammatory 25 cytokine mediators and contributes to hepatic ischemia-reperfusion injury (I/R). Currently, no 26 strategies to mitigate IRF1-mediated liver damage exist. Interferon regulatory factor 2 (IRF2) is a 27 structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF...

Hepatic injury caused by mianserin.

Hepatic cellular injury during varicella.

Serological evidence for hepatic cellular injury may occur during uncomplicated varicella. The magnitude of abnormalities may be helpful as a guide in the management of children with progressive varicella or varicella-associated Reye's syndrome, but liver function tests may be in the normal range. Viraemia was not detected during the acute stage of varicella-associated Reye's syndrome.

Role of thromboxane in producing hepatic injury during hepatic stress.

Hepatic injury after hepatic stress is caused by several mechanisms, including inflammatory reaction and microcirculatory disturbance. Levels of thromboxane, a vasoconstrictive eicosanoid, have been shown to increase in systemic circulation after different types of hepatic stress such as endotoxemia, hepatic ischemia-reperfusion, hepatectomy, liver transplantation, hemorrhagic shock and resusci...

Hepatic miR-29ab1 expression modulates chronic hepatic injury

MicroRNAs (miRNAs) are small, regulatory non-coding RNAs that have potent effects on gene expression. Several miRNA are deregulated in cellular processes involved in human liver diseases and regulation of cellular processes. Recent studies have identified the involvement of miR-29 in hepatic fibrosis and carcinogenesis. Although several targets of miR-29 have been identified, there is limited i...